Influence of dopaminergic receptor supersensitivity on anticonvulsant action of carbamazepine.

نویسندگان

  • S H Kadlimatti
  • R S Nadig
  • L Somaja
  • T Joseph
  • J David
چکیده

Dopamine (DA) receptor supersensitivity was induced in albino rats by haloperidol (5 mg/kg, ip day, for 18 days) and after 48 hr carbamazepine (CBZ) was administered in graded doses. The animals were subjected to Maximal Electroshock Seizures (MES) test, Minimal Electroconvulsive Threshold (MET) test and Pentylenetetrazole (PTZ)-induced convulsions test. Haloperidol pretreatment marginally increased the effect of CBZ against PTZ induced seizures, but not against electrically induced seizures (MES and MET tests).

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عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 32 4  شماره 

صفحات  -

تاریخ انتشار 1988